ࡱ> hjg'` MEbjbj 4J %8\H4'Lj"jKlKlKlKlKlKlK$MhOKQXXXKKN"N"N"XDjKN"XjKN"N"G&J| 2H".K<K0'LTH}P Z}PD&J}P&J`N"\ OKK!d'LXXXX  Curriculum Vitae: Swati Gupta University of Alabama at Birmingham (UAB) Shelby Interdisciplinary Biomedical Research Building 1825 University Boulevard Birmingham, AL 35294 (205) 447 5345 Email:  HYPERLINK "mailto:swatig@uab.edu" swatig@uab.edu Citizenship: USA Major Research Interests Molecular mechanisms involved: in learning and memory Education: 2001-2003 High school, Major: Science, Percentage: 90% Naval Childrens School, Mumbai- 5, India 2003-2006 BSc., Major: Lifesciences Minor: Biochemistry, marks: 662/800 St Xaviers College, Mumbai, India 2006-2008 Integrated Ph.D., Biological Sciences, NCBS, Bangalore-560065, India Advisor: Dr. Sumantra Chattarji Project title: Chromatin remodeling in the amygdala of stressed animals. 2008-Present Ph.D., Department of NeurobiologyUniversity of Alabama at Birmingham, AL Advisor: Dr. Farah Lubin Thesis title: Histone methylation regulation in the entorhinal cortex during long term memory consolidation Positions held: 2006-2008 Junior Research scholar, Advisor: Dr. Sumantra Chattarji, Neurobiology, NCBS, Bangalore, India 2008-Present Graduate Assistant, Advisor: Dr. Farah Lubin, Neurobiology, UAB, AL Awards and Honors: 2003: Top of my school in biology, chemistry and mathematics. 2004: Top of my university in Physics in first year of BSc. 2005-2006: I have completed Honors program in Life Sciences and Chemistry (16 credits). In Life Sciences: Academic Excellence, Garde: A Toxicology stidies using the chick embryo as a model system, the results of which were presented in a national conference held at University of Mumbai (2005), Grade: A Seminar series on recent advances in the Bioscience where in I presented on Syneasthesia, Grade: A In Chemistry: Academic Excellence, Grade: A Marine Sciences and Chemistry, Grade:B+ Chromatography techniques, Grade: A+ Basic Forensics, Garde: A 2008: I presented a poster on Chromatin modeling associated with stress in the amygdala of Rats for MCCS, Asia. Society Memberships: 2009- Present Member of Society for Neuroscience 2008- Present Member of Molecular and Cellular Cognitive Sciences. ManuscriptS: 1. S. Gupta, S. Kim, S. Artis, D.L. Molfese, A. Schumacher, R. Paylor, J.D. Sweatt, and F. Lubin. Histone methylation regulates memory formation. In review J. Neurosci. 2. S. Gupta, R. Parrish, and F. Lubin. A chapter on the Epigenetic regulation and translational medicine for the book, Translational Neuroscience: Applications in Neurology,Psychiatry, and Neurodevelopmental Disorders, Editor: Dr. James E. Barrett, Cambridge University Press. In preparation ABSTRACTS: 1. S. Gupta and F. Lubin. Histone methylation is dynamically regulated in the entorhinal cortex during consolidation of long-term memory.The Society for Neuroscience Annual Meeting, Chicago, IL. October 2009. 2. E. K. Lucas, S. Gupta, L. O. Wadiche, J. Lin, J. H. Meador-Woodruff, & R. M. Cowell. Multi-system deficiencies in parvalbumin in mice lacking the transcriptional coactivator PGC-1. The Society for Neuroscience Annual Meeting, Chicago, IL. October 2009. 3. S. Gupta and F. Lubin. Histone methylation: Following the hippocampus through fear memory. UAB Rotation poster, 2009 4. S. Gupta, E. K. Lucas, R. Cowell and L. O. Wadiche. GABA response in PGC1a knockout mice. UAB Rotation poster, 2008 Research Projects: 1. I worked on a 3 week project in Prof. Rohit Mittal s lab at T.I.F.R. where in I learned several biochemical techniques such as Western gel, transfections, induction, plasmid preparations etc. 2. I undertook the following research projects at National Centre for Biological Sciences: a. Novel molecules involved in the development and maintenance of the motor neuron-muscle-tendon circuit in Drosophila. The project involved testing of 200 molecules by means of an RNAi screen. These molecules were silenced in a tissue specific manner using three different GAL4 lines, restricting expression either to motoneurons, muscle cells or tendon cells. By using a Gal80ts background, it was established whether the molecule was involved in development or maintenance or both. b. Studying the role of syndecan molecules as a mechanosensors which are present on the surface of endothelial cells Using human umbilical vein endothelial cells, fibroblasts and endothelial cell line, I compared the distribution of syndecans, cell shape and size prior to and following different time points of flow conditions. The study suggested a possible role of syndecans as mechanosensors. c. Identifying cells undergoing chromatin modifications following a period of chronic immobilization stress within the hippocampus and amygdala Using immunohistochemistry I have probed for cells undergoing chromatin changes and hence identifying possible cells involved in storage of stressful memory within the amygdala. d. Effect of protein synthesis inhibitor on formation of stress memory Based on prior data from the lab, I behaviorally measured the memory of stress in rats which underwent a period of acute immobilization stress and injection with anisomycin (protein synthesis inhibitor). e. Perturbing histone acetylation levels in the brain and measuring its effects on memory i.p. injections of histone deacetylase inhibitor was administered following a period of acute immobilization stress in rats. The resultant memory of the stress was measures behaviorally using an elevated plus maze. Rotation Project undertaken at UAB: I worked on characterizing GABA responses in the PGC1a knockout mice under the guidance of Dr. Linda Wadiche. I characterized the spontaneous and evoked responses seen in the granule cells of the dentate gyrus in knockout, heterozygotes and wild type animals using the patch clamp technique. 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Current Research: I am working on dissecting out the epigenetic mechanisms underlying learning and memory. Specifically, I am looking at the regulation of histone methylation with consolidation in the EC of rats.     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